PT  - JOURNAL ARTICLE
AU  - Darius M Moshfeghi
AU  - Peter K Kaiser
AU  - Michael Gertner
TI  - Stereotactic low-voltage x-ray irradiation for age-related macular degeneration
AID  - 10.1136/bjo.2009.163907
DP  - 2011 Feb 01
TA  - British Journal of Ophthalmology
PG  - 185--188
VI  - 95
IP  - 2
4099  - http://bjo.bmj.com/content/95/2/185.short
4100  - http://bjo.bmj.com/content/95/2/185.full
SO  - Br J Ophthalmol2011 Feb 01; 95
AB  - The IRay stereotactic low-voltage x-ray irradiation treatment system for age-related macular degeneration consists of a low voltage x-ray tube, an eye tracking system, a robotically controlled delivery system, a coupling device to facilitate tracking and stabilisation, a graphical user interface and gating software. Low-voltage x-rays are delivered in a series of three spots to the macula in a non-invasive manner through the inferior pars plana. These beams are designed to overlap on the centre of the macula. Each beam delivers one-third of the total dose, such that the total macula dose is three times an individual beam's dose. The device is designed to run off standard domestic electrical power, and no special shielding is necessary for the room. This system has been validated in Monte Carlo simulations, human cadaver eye studies, pre-clinical animal studies and in a phase I clinical trial.