PT  - JOURNAL ARTICLE
AU  - Benjamin Guigui
AU  - Nicolas Leveziel
AU  - Virginie Martinet
AU  - Nathalie Massamba
AU  - Margaret Sterkers
AU  - Gabriel Coscas
AU  - Eric H Souied
TI  - Angiography features of early onset drusen
AID  - 10.1136/bjo.2009.178400
DP  - 2011 Feb 01
TA  - British Journal of Ophthalmology
PG  - 238--244
VI  - 95
IP  - 2
4099  - http://bjo.bmj.com/content/95/2/238.short
4100  - http://bjo.bmj.com/content/95/2/238.full
SO  - Br J Ophthalmol2011 Feb 01; 95
AB  - Aims Drusen are rarely observed in patients <50 years of age. Two types of early onset drusen (EOD) are commonly described: basal laminar drusen (BLD) and drusen associated with Malattia Leventinese (ML). Our purpose was to classify the phenotype of EOD on the basis of fundus examination, and fluorescein angiography (FA) and indocyanine green angiography (ICGA) features.Methods We performed a prospective study including 48 consecutive EOD patients. All of them had a complete ophthalmologic examination including FA and ICGA.Results BLD (67%) were extremely hyperfluorescent on FA and ICGA. ML (10%) was characterised by a combination of small radial and large round drusen with differences in staining in both FA and ICGA. We evidenced a third type of EOD (23%) harbouring an aspect of large colloid drusen (LCD), mildly hyperfluorescent in the early phases of FA, with a progressive staining in late phases. In intermediate and late phases of ICGA, LCD presented as hypofluorescent dot surrounded by a hyperfluorescent halo bordered by a thin hypofluorescent ring.Conclusion Three types of EOD are distinguished by their FA and ICGA features. We report a new kind of juvenile drusen, distinct from BLD and ML, named LCD, associated with a good vision and absence of complications.