PT  - JOURNAL ARTICLE
AU  - Perumal Jayaraj
AU  - Seema Sen
AU  - Seema Kashyap
AU  - Anjana Sharma
AU  - Neelam Pushker
AU  - Mandeep Singh Bajaj
AU  - Supriyo Ghose
AU  - Kunzang Chosdol
TI  - Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid?
AID  - 10.1136/bjo.2009.177204
DP  - 2011 Feb 01
TA  - British Journal of Ophthalmology
PG  - 284--287
VI  - 95
IP  - 2
4099  - http://bjo.bmj.com/content/95/2/284.short
4100  - http://bjo.bmj.com/content/95/2/284.full
SO  - Br J Ophthalmol2011 Feb 01; 95
AB  - Aim Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features.Method 48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.Resuts Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size >2 cm (p=0.242). Nuclear staining was not observed in any of the cases.Conclusion Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further.