TY - JOUR T1 - Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid? JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 284 LP - 287 DO - 10.1136/bjo.2009.177204 VL - 95 IS - 2 AU - Perumal Jayaraj AU - Seema Sen AU - Seema Kashyap AU - Anjana Sharma AU - Neelam Pushker AU - Mandeep Singh Bajaj AU - Supriyo Ghose AU - Kunzang Chosdol Y1 - 2011/02/01 UR - http://bjo.bmj.com/content/95/2/284.abstract N2 - Aim Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features.Method 48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.Resuts Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size >2 cm (p=0.242). Nuclear staining was not observed in any of the cases.Conclusion Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further. ER -