RT Journal Article
SR Electronic
T1 Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid?
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 284
OP 287
DO 10.1136/bjo.2009.177204
VO 95
IS 2
A1 Jayaraj, Perumal
A1 Sen, Seema
A1 Kashyap, Seema
A1 Sharma, Anjana
A1 Pushker, Neelam
A1 Bajaj, Mandeep Singh
A1 Ghose, Supriyo
A1 Chosdol, Kunzang
YR 2011
UL http://bjo.bmj.com/content/95/2/284.abstract
AB Aim Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features.Method 48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.Resuts Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size >2 cm (p=0.242). Nuclear staining was not observed in any of the cases.Conclusion Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further.