PT - JOURNAL ARTICLE AU - Ahuja, A K AU - Dorn, J D AU - Caspi, A AU - McMahon, M J AU - Dagnelie, G AU - daCruz, L AU - Stanga, P AU - Humayun, M S AU - Greenberg, R J AU - Argus II Study Group TI - Blind subjects implanted with the Argus II retinal prosthesis are able to improve performance in a spatial-motor task AID - 10.1136/bjo.2010.179622 DP - 2011 Apr 01 TA - British Journal of Ophthalmology PG - 539--543 VI - 95 IP - 4 4099 - http://bjo.bmj.com/content/95/4/539.short 4100 - http://bjo.bmj.com/content/95/4/539.full SO - Br J Ophthalmol2011 Apr 01; 95 AB - Background/aims To determine to what extent subjects implanted with the Argus II retinal prosthesis can improve performance compared with residual native vision in a spatial-motor task.Methods High-contrast square stimuli (5.85 cm sides) were displayed in random locations on a 19″ (48.3 cm) touch screen monitor located 12″ (30.5 cm) in front of the subject. Subjects were instructed to locate and touch the square centre with the system on and then off (40 trials each). The coordinates of the square centre and location touched were recorded.Results Ninety-six percent (26/27) of subjects showed a significant improvement in accuracy and 93% (25/27) show a significant improvement in repeatability with the system on compared with off (p<0.05, Student t test). A group of five subjects that had both accuracy and repeatability values <250 pixels (7.4 cm) with the system off (ie, using only their residual vision) was significantly more accurate and repeatable than the remainder of the cohort (p<0.01). Of this group, four subjects showed a significant improvement in both accuracy and repeatability with the system on.Conclusion In a study on the largest cohort of visual prosthesis recipients to date, we found that artificial vision augments information from existing vision in a spatial-motor task.Clinical trials registry no NCT00407602.