TY - JOUR T1 - Highlights from this issue JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1 LP - 1 DO - 10.1136/bjophthalmol-2011-300636 VL - 95 IS - 8 AU - Harminder S Dua AU - Arun D Singh Y1 - 2011/08/01 UR - http://bjo.bmj.com/content/95/8/1.abstract N2 - Oberacher-Velten et al investigated the effects of oral midazolam on intraocular pressure (IOP) in children (72 eyes of 36 children without glaucoma) requiring general anaesthesia by using a Perkins hand-held tonometer. Measurements of IOP were performed before, and 15 and 30 min after sedation with orally administered midazolam (1 mg/kg) and 5 and 15 min after induction of general anaesthesia. The mean IOP before sedation (11.2), at 15 min (10.9) and at 30 min (10.7) after administration of midazolam was not significantly different. However, IOP decline at 5 min (8.1) and 15 min (6.8) after induction of general anaesthesia was statistically significant. (See page 1102)Deissler et al measured changes in transendothelial electrical resistance and expression of claudin-1 as a measure of cellular permeability and as an indicator of functional tight junctions respectively, in immortalised retinal endothelial cells (iBREC) in the absence or presence of ranibizumab or KRN951 (inhibitor of vascular endothelial growth factor (VEGF) receptors). Whereas VEGF165 decreased transendothelial electrical resistance and expression of claudin-1 … ER -