PT  - JOURNAL ARTICLE
AU  - Yasuyuki Yamauchi
AU  - Tsuyoshi Agawa
AU  - Rintaro Tsukahara
AU  - Keisuke Kimura
AU  - Naoyuki Yamakawa
AU  - Masahiro Miura
AU  - Hiroshi Goto
TI  - Correlation between high-resolution optical coherence tomography (OCT) images and histopathology in an iodoacetic acid-induced model of retinal degeneration in rabbits
AID  - 10.1136/bjo.2010.186718
DP  - 2011 Aug 01
TA  - British Journal of Ophthalmology
PG  - 1157--1160
VI  - 95
IP  - 8
4099  - http://bjo.bmj.com/content/95/8/1157.short
4100  - http://bjo.bmj.com/content/95/8/1157.full
SO  - Br J Ophthalmol2011 Aug 01; 95
AB  - Background Recent research on macular disease has prompted investigation into the condition of the intersection of the inner and outer segments (IS/OS) and its relationship with retinal photoreceptor abnormalities. Because the relationship between optical coherence tomography (OCT) images and histopathology is unclear, we compared these in an iodoacetic acid (IAA)-induced model of photoreceptor degeneration in rabbits.Methods IAA (20 mg/kg), which is toxic to photoreceptors, was injected into six coloured rabbits. After IAA administration, nine retinas were used for histopathological study: three from rabbits surviving for 1 day and six from rabbits surviving for 4 months. Four healthy rabbit retinas served as controls. OCT images were taken before euthanasia.Results In the controls, OCT images revealed the IS/OS as a clear, straight line. In rabbits surviving for 1 day, the structure of the photoreceptor IS/OS was destroyed and the IS/OS boundary was not visible. In rabbits surviving for 4 months, the IS was still preserved, but the structure of the OS was destroyed or partially disorganised, and the IS/OS was observed as a wavy, broken line on the OCT images.Conclusion The IS/OS on the OCT images reflected the histopathology of the inner and outer segments in a photoreceptor degeneration model.