RT Journal Article SR Electronic T1 Detection of early functional changes in diabetic retina using slow double-stimulation mfERG paradigm JF British Journal of Ophthalmology JO Br J Ophthalmol FD BMJ Publishing Group Ltd. SP 1560 OP 1563 DO 10.1136/bjo.2010.192476 VO 95 IS 11 A1 Chan, Henry Ho-lung A1 Chu, Patrick Ho-wai A1 Lung, Jenny Chun-yee A1 Ho, Wing-cheung A1 Ting, Patrick Wai-ki A1 Sum, Rita Wing-man A1 Ng, Yiu-fai YR 2011 UL http://bjo.bmj.com/content/95/11/1560.abstract AB Aim Diabetes mellitus (DM) is a systemic disease with insufficient secretion of insulin or poor response to insulin. This typically causes poor control of blood glucose level leading to a range of complications. Early detection of the retinal function alteration in DM is needed.Methods A newly modified paradigm—slow double-stimulation multifocal electroretinogram (mfERG)—was introduced to measure early changes of retinal function in DM and to investigate changes in the adaptation mechanisms in the diabetic retina. The mfERG was measured by using a slow double-stimulation mfERG paradigm (M1M2OOO).Results The m1 amplitude of M1 stimulation from diabetic subjects was significantly reduced in ring 1 in contrast to that of a control group. The m2 amplitude of M2 stimulation from diabetic subjects was also significantly reduced in ring 1 and 2 as compared with those of the control group. The m1/m2 ratio which minimises intersubject variation shows a reasonable differentiation between the control and diabetic groups. There was a significant increase in the amplitude ratio from diabetic subjects in ring 2 and 3 as compared with those of the control group.Conclusions The present findings suggest that the new mfERG paradigm is a fast and sensitive test for the detection of early functional changes in the diabetic retina.