PT  - JOURNAL ARTICLE
AU  - Foo, Li-Lian
AU  - Perera, Shamira A
AU  - Cheung, Carol Y
AU  - Allen, John C
AU  - Zheng, Yingfeng
AU  - Loon, Seng-Chee
AU  - Wong, Tien Y
AU  - Aung, Tin
TI  - Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters
AID  - 10.1136/bjophthalmol-2011-300835
DP  - 2012 Apr 01
TA  - British Journal of Ophthalmology
PG  - 576--580
VI  - 96
IP  - 4
4099  - http://bjo.bmj.com/content/96/4/576.short
4100  - http://bjo.bmj.com/content/96/4/576.full
SO  - Br J Ophthalmol2012 Apr 01; 96
AB  - Objective To investigate the agreement between scanning laser ophthalmoscopy (Heidelberg retinal tomograph 3; HRT-3) and high-definition optical coherence tomography (HD–OCT) for measurements of optic nerve head (ONH) parameters.Methods As part of a population-based cross-sectional study, 913 consecutive Chinese subjects aged 40 years and older underwent HRT-3 and HD–OCT imaging of the ONH after pupillary dilation. Limits of agreement (LOA) derived from Bland–Altman analysis were calculated for ONH measurements.Results The mean age (±SD) of study participants was 54.2±7.2 years and 52.0% were men. The two instruments showed no difference in mean optic disc area measurements (1.98±0.37 for HD–OCT vs 1.98±0.39 mm for HRT-3, p=0.95). HD–OCT showed smaller rim area (1.29±0.24 vs 1.46±0.27 mm, p<0.001), but bigger cup-related parameters (p<0.001 for all) than HRT-3. The highest correlations between the instruments were observed for cup volume (r2=0.74, p<0.001) and disc area (r2=0.62, p<0.001). The correlations for cup-to-disc ratio (CDR), vertical CDR and rim area were lower (r2=0.59, 0.48 and 0.24, respectively, p<0.001 for all). The Bland–Altman plots demonstrated significant proportional bias for differences in all ONH parameters (p<0.01 for all), with LOA greater for disc-related parameters (0.98–1.0) than cup-related parameters (0.26–0.50).Conclusions There are substantial disagreements between HRT-3 and HD–OCT in ONH measurements. Although optic disc area measurements were similar, HD–OCT underestimates the rim area and overestimates cup parameters compared with HRT-3.