TY - JOUR T1 - Repeatability of measurements of effectiveness of glaucoma medication JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1494 LP - 1497 DO - 10.1136/bjophthalmol-2012-301877 VL - 96 IS - 12 AU - Alan P Rotchford AU - Anthony J King Y1 - 2012/12/01 UR - http://bjo.bmj.com/content/96/12/1494.abstract N2 - Aims To determine short-term repeatability of the effect of intraocular pressure (IOP) reducing medication and the number of repeated measurements necessary to estimate therapeutic effect with a given degree of precision. Methods IOP was measured at 8:00, 11:00 and 16:00 h at each of three weekly visits in untreated patients with primary open-angle glaucoma or ocular hypertension. After starting travaprost (0.004%) to both eyes, the measurements were repeated for a further three weekly visits. Repeatability of the change in IOP 1, 2 and 3 weeks after starting treatment was reported as the coefficient of repeatability (CR) and coefficient of variability (CV). Results Mean reduction in IOP was 7.5 mm Hg (29.9%). CR and CV between visits were 7.8 mm Hg and 37.2%, respectively. Repeated estimates of the effectiveness of treatment in the same subject at the same time of day would, therefore, be expected to lie within a range of 7.8 mm Hg and within ±73.2% of the mean effect with 95% confidence. A reduction in IOP less than 7.8 mm Hg over a single pair of measurements would be indistinguishable from measurement error. Precision improves from ±73.2% for a single pair of readings to ±25.9% for eight pairs. Conclusions Day-to-day repeatability in the estimation of medication effectiveness is poor even for time-of-day standardised measurements and the number of IOP measurements required to achieve precision adequate for use in clinical practice is large. ER -