RT Journal Article
SR Electronic
T1 Retinal thinning and correlation with functional disability in patients with Parkinson's disease
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 350
OP 355
DO 10.1136/bjophthalmol-2013-304152
VO 98
IS 3
A1 M Satue
A1 M Seral
A1 S Otin
A1 R Alarcia
A1 R Herrero
A1 M P Bambo
A1 M I Fuertes
A1 L E Pablo
A1 E Garcia-Martin
YR 2014
UL http://bjo.bmj.com/content/98/3/350.abstract
AB Aims To determine whether there is an association between retinal thinning and functional rating scales in patients with Parkinson's disease (PD). Materials and methods Patients with PD (n=153) and controls (n=242) underwent evaluations of the macula and retinal nerve fibre layer (RNFL) using two new-generation Fourier domain optical coherence tomography (OCT) devices (Cirrus, Carl Zeiss Meditec, Dublin, California, USA; Spectralis, Heidelberg Engineering, Heidelberg, Germany). PD severity was assessed using the Schwab-England Activities of Daily Living scale, the Unified Parkinson Disease Rating Scale, the Hoehn and Yahr (HY) scale. Retinal and RNFL thicknesses were compared between patients and controls. Correlations between structural parameters and the scores of the neurologic scales were evaluated. Results RNFL parameters were significantly reduced in patients with PD, especially when using the Spectralis OCT device. All macular parameters, except for foveal thickness, differed significantly between controls and patients with PD (p<0.001). HY scores were significantly and inversely correlated with all macular parameters when measured with the Spectralis OCT device (p<0.05) and with RNFL thickness when measured with the Cirrus OCT device (nasal quadrant, sectors 2 and 5). Conclusions The neurodegeneration caused by PD can be detected using Fourier domain OCT. RNFL and macular thicknesses correlate with PD severity.