RT Journal Article SR Electronic T1 What is the evidence for systemic effects of intravitreal anti-VEGF agents, and should we be concerned? JF British Journal of Ophthalmology JO Br J Ophthalmol FD BMJ Publishing Group Ltd. SP i7 OP i10 DO 10.1136/bjophthalmol-2013-303844 VO 98 IS Suppl 1 A1 Avery, Robert L YR 2014 UL http://bjo.bmj.com/content/98/Suppl_1/i7.abstract AB Anti-vascular endothelial growth factor (VEGF) therapy has revolutionised the treatment of retinal disease, and appears to be very safe. Nevertheless, there are several lines of evidence that imply that small doses of these agents could potentially have a systemic effect. The clinical significance of these systemic effects remains unclear, but further study is indicated.