RT Journal Article
SR Electronic
T1 Quantification of cone loss after surgery for retinal detachment involving the macula using adaptive optics
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1343
OP 1348
DO 10.1136/bjophthalmol-2013-304813
VO 98
IS 10
A1 M Saleh
A1 G Debellemanière
A1 M Meillat
A1 P Tumahai
A1 M Bidaut Garnier
A1 M Flores
A1 C Schwartz
A1 B Delbosc
YR 2014
UL http://bjo.bmj.com/content/98/10/1343.abstract
AB Aims To image the cones in eyes with anatomically successful repair of retinal detachment (RD) involving the macula and in healthy fellow eyes using an adaptive optics (AO) camera and to correlate the results to clinical outcomes. Methods Twenty-one patients (42 eyes) operated for macula-off RD were imaged 6 weeks after surgery using an AO camera (RTX 1, Imagine Eyes, Orsay, France). Cone density (cells/mm2), spacing between cells (µm) and the percentage of cones with six neighbours were measured. Best-corrected visual acuity (BCVA) and thickness of the inner segment ellipsoid (ISe) band imaged by SD-optical coherence tomography were also measured. Results The parafoveal cone density was decreased in eyes operated for RD (mean±SD 14 576±4035/mm2) compared with fellow eyes (20 589±2350/mm2) (p=0.0001). There was also an increase in cone spacing (10.3±2.6 vs 8.0±1.0.9 µm, respectively, p<0.0001). The nearest-neighbour analysis revealed a reduction in the percentage of cones with six neighbours (36.5±4.2 vs 42.7±4.6%, p=0.0003). The ISe thickness, thinner in the operated eyes, was correlated to the cone density (r=0.62, p<0.0001). BCVA was significantly correlated to cone density (r=0.8, p<0.001). Conclusions There was a decrease in the cone density after RD with an estimated loss of one-third of the cones. Postoperative visual acuity was highly correlated with the cone density. AO may be a valuable prognostic tool after RD surgery.