PT  - JOURNAL ARTICLE
AU  - Tracy B Høeg
AU  - Birgitte Moldow
AU  - Ronald Klein
AU  - Morten La Cour
AU  - Kristian Klemp
AU  - Ditte Erngaard
AU  - Christina Ellervik
AU  - Helena Buch
TI  - An evaluation of fundus photography and fundus autofluorescence in the diagnosis of cuticular drusen
AID  - 10.1136/bjophthalmol-2015-307197
DP  - 2016 Mar 01
TA  - British Journal of Ophthalmology
PG  - 378--382
VI  - 100
IP  - 3
4099  - http://bjo.bmj.com/content/100/3/378.short
4100  - http://bjo.bmj.com/content/100/3/378.full
SO  - Br J Ophthalmol2016 Mar 01; 100
AB  - Purpose To examine non-mydriatic fundus photography (FP) and fundus autofluorescence (FAF) as alternative non-invasive imaging modalities to fluorescein angiography (FA) in the detection of cuticular drusen (CD).Methods Among 2953 adults from the Danish Rural Eye Study (DRES) with gradable FP, three study groups were selected: (1) All those with suspected CD without age-related macular degeneration (AMD) on FP, (2) all those with suspected CD with AMD on FP and (3) a randomly selected group with early AMD. Groups 1, 2 and 3 underwent FA and FAF and group 4 underwent FAF only as part of DRES CD substudy. Main outcome measures included percentage of correct positive and correct negative diagnoses, Cohen's κ and prevalence-adjusted and bias-adjusted κ (PABAK) coefficients of test and grader reliability.Results CD was correctly identified on FP 88.9% of the time and correctly identified as not being present 83.3% of the time. CD was correctly identified on FAF 62.0% of the time and correctly identified as not being present 100.0% of the time. Compared with FA, FP has a PABAK of 0.75 (0.60 to 1.5) and FAF a PABAK of 0.44 (0.23 to 0.95).Conclusions FP is a promising, non-invasive substitute for FA in the diagnosis of CD. FAF was less reliable than FP to detect CD.