RT Journal Article
SR Electronic
T1 Weight at first detection of retinopathy of prematurity predicts disease severity
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1565
OP 1569
DO 10.1136/bjophthalmol-2014-304905
VO 98
IS 11
A1 Pia Lundgren
A1 Åsa Wilde
A1 Chatarina Löfqvist
A1 Lois E H Smith
A1 Anna-Lena Hård
A1 Ann Hellström
YR 2014
UL http://bjo.bmj.com/content/98/11/1565.abstract
AB Objective To investigate whether postnatal weight at first detection of retinopathy of prematurity (ROP) can predict preterm infants who will develop severe ROP warranting treatment. Design This modern, population-based cohort included 147 infants born at gestational age (GA) <32 weeks in the Gothenburg region during 2011–2012 and screened for ROP at Sahlgrenska University hospital. GA, birth weight (BW), and weekly postnatal weight from birth until postmenstrual age (PMA) 40 weeks data were retrospectively retrieved. Birth weight SD scores (BWSDS) were calculated. ROP data, including first detected ROP stage, maximal ROP stage, ROP treatment, and PMA at first detected sign of ROP were also retrieved. Weight SDS (WSDS) at first ROP detection was calculated. Results Stepwise multivariate logistic regression analysis revealed that the best fit-model of risk factors for developing severe ROP warranting treatment included; GA (OR=0.28, CI 95% 0.12 to 0.66, p<0.01) and WSDS at first ROP detection (OR=0.22, CI 95% 0.05 to 0.89, p<0.05). Conclusions Low weight and low WSDS at first ROP detection can be useful predictors for ROP warranting treatment.