TY - JOUR T1 - Macular structure–function relationship at various spatial locations in glaucoma JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1412 LP - 1418 DO - 10.1136/bjophthalmol-2014-306538 VL - 99 IS - 10 AU - Soa Kim AU - Jin Young Lee AU - Seon-Ok Kim AU - Michael S Kook Y1 - 2015/10/01 UR - http://bjo.bmj.com/content/99/10/1412.abstract N2 - Background/aims To study whether the structure–function (S-F) relationship in glaucoma differs according to macular location using spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry 10-2 and 24-2 visual fields (VFs).Methods We enrolled 151 eyes of 151 healthy, preperimetric and perimetric glaucomatous subjects. Macular ganglion cell-inner plexiform layer thicknesses at different parafoveal locations were measured using Cirrus SD-OCT. The mean sensitivity of 10–2 and 24–2 VFs was recorded in the decibel and 1/L scales. The topographic relationships between structure and function were assessed at different parafoveal and hemimacular locations using ‘weighted’ correlation coefficients. The strength of S-F relationships between macular ganglion cell-inner plexiform layer thickness measurements and VF mean sensitivity in various parafoveal locations and in superior and inferior hemimacula was compared using Steiger's test.Results The temporal parafoveal sector showed a significantly greater S-F relationship in each hemimacula compared with other parafoveal sectors (p<0.05). The inferior hemimacula showed a significantly greater S-F relationship than superior hemimacula (p<0.001).Conclusions The strength of the S-F associations at the temporal parafoveal location is significantly greater than that of the central or nasal parafoveal location in each hemimacula. The strength of the S-F association is significantly greater in the inferior hemimacula than in the superior hemimacula. ER -