@article {Sharma1503, author = {Namrata Sharma and Gautam Sinha and Himanshu Shekhar and Jeewan S Titiyal and Tushar Agarwal and Bhavna Chawla and Radhika Tandon and Rasik B Vajpayee}, title = {Demographic profile, clinical features and outcome of peripheral ulcerative keratitis: a prospective study}, volume = {99}, number = {11}, pages = {1503--1508}, year = {2015}, doi = {10.1136/bjophthalmol-2014-306008}, publisher = {BMJ Publishing Group Ltd}, abstract = {Purpose To evaluate aetiology, demographic profile, clinical features and outcomes in cases of peripheral ulcerative keratitis (PUK).Methods Seventy-six eyes of 65 consecutive patients with PUK were evaluated in this prospective interventional study over an 18 month period, which were followed for 3 years. The main outcome measures were sociodemographic profile, aetiology, clinical features, management strategies and outcome.Results Sixty per cent (39/65) of cases were men and mean age was 45.5{\textpm}17.9 years. Two-thirds (43/65) of the patients were from rural areas with majority (48/65) belonging to low socioeconomic status. Unilateral disease was present in 83\% of patients (54/65) with nasal involvement in 60.5\% (46/76) cases. The most common aetiology was Mooren{\textquoteright}s ulcer (31.5\% cases (24/76 eyes)) followed by infection and systemic collagen vascular disease. Meibomian gland dysfunction (17/76: 22.3\%) was the most common extraocular association and complicated cataract (12/76:15.7\%) was the most common intraocular abnormality. In mild and moderate cases, no significant visual improvement was observed (p=0.085 and p=0.156) as compared with the pretreatment status. Surgical treatment was successful in maintaining anatomical integrity in 83.3\% (30/36) eyes. Recurrence of the disease was seen in one eye in moderate disease and three eyes in severe disease.Conclusions Mooren{\textquoteright}s ulcer followed by collagen vascular diseases and infection are important causes of PUK in developing countries. Surgical intervention in perforated cases had good anatomical success and visual prognosis.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/99/11/1503}, eprint = {https://bjo.bmj.com/content/99/11/1503.full.pdf}, journal = {British Journal of Ophthalmology} }