RT Journal Article
SR Electronic
T1 Retinal angiography with real-time speckle variance optical coherence tomography
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2014-306010
DO 10.1136/bjophthalmol-2014-306010
A1 Jing Xu
A1 Sherry Han
A1 Chandrakumar Balaratnasingam
A1 Zaid Mammo
A1 Kevin S K Wong
A1 Sieun Lee
A1 Michelle Cua
A1 Mei Young
A1 Andrew Kirker
A1 David Albiani
A1 Farzin Forooghian
A1 Paul Mackenzie
A1 Andrew Merkur
A1 Dao-Yi Yu
A1 Marinko V Sarunic
YR 2015
UL http://bjo.bmj.com/content/early/2015/03/02/bjophthalmol-2014-306010.abstract
AB This report describes a novel, non-invasive and label-free optical imaging technique, speckle variance optical coherence tomography (svOCT), for visualising blood flow within human retinal capillary networks. This imaging system uses a custom-built swept source OCT system operating at a line rate of 100 kHz. Real-time processing and visualisation is implemented on a consumer grade graphics processing unit. To investigate the quality of microvascular detail acquired with this device we compared images of human capillary networks acquired with svOCT and fluorescein angiography. We found that the density of capillary microvasculature acquired with this svOCT device was visibly greater than fluorescein angiography. We also found that this svOCT device had the capacity to generate en face images of distinct capillary networks that are morphologically comparable with previously published histological studies. Finally, we found that this svOCT device has the ability to non-invasively illustrate the common manifestations of diabetic retinopathy and retinal vascular occlusion. The results of this study suggest that graphics processing unit accelerated svOCT has the potential to non-invasively provide useful quantitative information about human retinal capillary networks. Therefore svOCT may have clinical and research applications for the management of retinal microvascular diseases, which are a major cause of visual morbidity worldwide.