PT  - JOURNAL ARTICLE
AU  - N Yamada
AU  - R Matsuda
AU  - N Morishige
AU  - R Yanai
AU  - T-i Chikama
AU  - T Nishida
AU  - T Ishimitsu
AU  - A Kamiya
TI  - Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy
AID  - 10.1136/bjo.2007.130013
DP  - 2008 Jul 01
TA  - British Journal of Ophthalmology
PG  - 896--900
VI  - 92
IP  - 7
4099  - http://bjo.bmj.com/content/92/7/896.short
4100  - http://bjo.bmj.com/content/92/7/896.full
SO  - Br J Ophthalmol2008 Jul 01; 92
AB  - Background/aims: Loss of corneal sensation results in the development of persistent corneal epithelial defects. The combination of a substance P-derived peptide (FGLM-amide) and an insulin-like growth factor-1 (IGF-1)-derived peptide (SSSR) stimulates rabbit corneal epithelial migration in vitro and rabbit corneal epithelial wound closure in vivo. The clinical efficacy of eye-drops containing FGLM-amide and SSSR for the treatment of persistent corneal epithelial defects in individuals with neurotrophic keratopathy was examined in a prospective open study.Methods: Twenty-five consecutive patients (26 eyes) with persistent corneal epithelial defects associated with neurotrophic keratopathy were treated by administration of eye-drops containing FGLM-amide and SSSR. The course of epithelial healing was monitored by slit-lamp examination.Results: Epithelial defects resurfaced completely in 19 of the 26 eyes (73%) within 4 weeks after treatment initiation. Complete resurfacing of epithelial defects was apparent in 18 of 22 (82%) or in one of four (25%) eyes without or with limbal stem cell deficiency, respectively. No adverse effects of treatment were observed in any subject.Conclusion: Eye-drops containing FGLM-amide and SSSR induced the rapid resurfacing of persistent epithelial defects in stem cell-positive individuals with neurotrophic keratopathy.