PT - JOURNAL ARTICLE AU - G A Epstein AU - M F Rabb TI - Adult vitelliform macular degeneration: diagnosis and natural history. AID - 10.1136/bjo.64.10.733 DP - 1980 Oct 01 TA - British Journal of Ophthalmology PG - 733--740 VI - 64 IP - 10 4099 - http://bjo.bmj.com/content/64/10/733.short 4100 - http://bjo.bmj.com/content/64/10/733.full SO - Br J Ophthalmol1980 Oct 01; 64 AB - True vitelliform dystrophy rarely appears in the adult population. We describe 10 cases in adults of bilateral vitelliform lesions clinically mistaken for Best's disease. Fluorescein angiography is a useful tool in distinguishing this dystrophy from Best's disease or other diseases. The angiographic findings suggest pigment epithelial disease. Adult vitelliform degeneration may lead to dry atrophic macular degeneration in a similar fashion as macular drusen. Symptoms and visual findings in these patients are fairly stable, and may be only slowly progressive in spite of ophthalmoscopic and fluorescein angiographic changes over a period of years. The electro-oculogram is useful in separating adult vitelliform macular degeneration from true vitelliform dystrophy.