RT Journal Article SR Electronic T1 Improved iodine-125 plaque design in the treatment of choroidal malignant melanoma. JF British Journal of Ophthalmology JO Br J Ophthalmol FD BMJ Publishing Group Ltd. SP 91 OP 94 DO 10.1136/bjo.76.2.91 VO 76 IS 2 A1 J C Hill A1 R Sealy A1 D Shackleton A1 C Stannard A1 J Korrubel A1 E Hering A1 C Loxton YR 1992 UL http://bjo.bmj.com/content/76/2/91.abstract AB The use and development of iodine-125 plaque therapy for choroidal malignant melanoma are described. Since 1975 experience has led to changes in plaque design and insertion techniques. Twenty-one patients were irradiated with local episcleral iodine-125 plaques. Three patients required a second plaque for tumour recurrence. Four eyes were enucleated because of continued tumour growth and a further eye was removed because of glaucoma secondary to radiation retinopathy. Two patients (9.5%) died of metastases. The remaining 19 patients are alive and clinically clear of metastases, with a mean follow up time of 73.1 months (range 43-142 months).