PT  - JOURNAL ARTICLE
AU  - Jin Young Lee
AU  - Kyung Rim Sung
AU  - Sung-Cheol Yun
TI  - Comparison of rates of retinal nerve fibre layer thinning between patients with non-myopic and myopic glaucoma
AID  - 10.1136/bjophthalmol-2015-307343
DP  - 2016 May 01
TA  - British Journal of Ophthalmology
PG  - 699--703
VI  - 100
IP  - 5
4099  - http://bjo.bmj.com/content/100/5/699.short
4100  - http://bjo.bmj.com/content/100/5/699.full
SO  - Br J Ophthalmol2016 May 01; 100
AB  - Background/aim To compare the rates of retinal nerve fibre layer (RNFL) thinning in subgroups of patients with glaucoma based on spherical equivalent (SE).Methods In this retrospective study, patients were classified into three subgroups, namely, non-myopic glaucoma (NMG, >0 dioptres (D)), mild-to-moderate glaucoma (MMG, 0 to −6 D) and highly myopic glaucoma (HMG,<−6 D), according to their SE. Linear mixed effects models were used to evaluate the rate of change of RNFL thickness determined by spectral domain optical coherence tomography, adjusting for potentially confounding factors.Results Among 231 glaucomatous eyes from 231 patients (mean followed up 4.5 years), 105 (45.5%) were classified as NMG, 100 (43.2%) as MMG and 26 (11.3%) as HMG. Baseline visual field mean deviation did not differ among the three subgroups (−4.15 vs −5.44 dB vs −4.38 dB, p=0.185). Thinning rate of average RNFL did not differ among the three subgroups (−0.58, −0.52 and −0.54 μm/year, p=0.931). However, RNFL thinning rate at temporal quadrant (−0.85 vs −0.23 μm/year, p=0.046) and eight o’clock sector was greater in the HMG than in the NMG subgroups (−1.72 vs −0.35 μm/year, p=0.003), while that of one o'clock sector was greater in the NMG than in the HMG subgroups (−0.93 vs 0.45 μm/year, p=0.009).Conclusion Overall rate of RNFL thinning was not different among the glaucoma subgroups based on refractive error. However, sectoral RNFL thinning showed significant difference.