RT Journal Article
SR Electronic
T1 Choroidal maps in non-exudative age-related macular degeneration
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 677
OP 682
DO 10.1136/bjophthalmol-2015-307169
VO 100
IS 5
A1 Capuano, Vittorio
A1 Souied, Eric H
A1 Miere, Alexandra
A1 Jung, Camille
A1 Costanzo, Eliana
A1 Querques, Giuseppe
YR 2016
UL http://bjo.bmj.com/content/100/5/677.abstract
AB Purpose To compare choroidal thickness maps (CMs) in patients with non-exudative age-related macular degeneration (AMD) and control subjects using swept source optical coherence tomography (Swept-OCT).Methods CMs were automatically measured in the different Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors in eyes with early non-exudative AMD (early AMD) (large soft drusen: group 1; reticular pseudodrusen: group 2 and variable combination of large soft drusen and reticular pseudodrusen: group 3), late non-exudative AMD/geographic atrophy (GA) (late AMD) (group 4) and control subjects (group 5). Fundus autofluorescence (FAF) images were overlaid to sectorial CMs in late-AMD group (group 4).Results A total of 90 eyes (90 patients, 79.7±8.34 years old) were included. CMs were significantly reduced in early-AMD group 2 and 3 and late-AMD group 4 compared with control subjects in group 5 and early-AMD group 1 (large soft drusen alone) for each ETDRS sectors (p<0.05). No difference in CMs was found by comparing group 2 with 3 and group 2 and 3 with group 4. No statistical differences in CMs were found among ETDRS sectors with >50% absence of FAF (‘Hypo FAF’ sectors) resulting from retinal atrophy versus ≤50% absence of FAF (‘hyper/iso FAF’ sectors owing to >50% preserved retina) in late-AMD group (group 4) (p=0.328).Conclusions CMs appeared thinner in early non-exudative AMD with intermediate distribution of reticular pseudodrusen versus control subjects and early non-exudative AMD with drusen alone. Same results were found in the group with variable combination of large soft drusen and reticular pseudodrusen. In GA eyes, a choroidal thinning could be detected independently of the retinal pigmented epithelium status.