@article {Ruiters879, author = {S{\'e}bastien Ruiters and Yi Sun and St{\'e}phan de Jong and Constantinus Politis and Ilse Mombaerts}, title = {Computer-aided design and three-dimensional printing in the manufacturing of an ocular prosthesis}, volume = {100}, number = {7}, pages = {879--881}, year = {2016}, doi = {10.1136/bjophthalmol-2016-308399}, publisher = {BMJ Publishing Group Ltd}, abstract = {Restoring the facial appearance in acquired anophthalmos entails precision fitting of a customised ocular prosthesis. The fabrication is an artisanal process, and is primarily based on an impression of the anophthalmic cavity. This is usually achieved by the impression-moulding method, which, however, may introduce errors, resulting in a poorly fitted prosthesis. We developed a new method in the manufacturing of a customised ocular prosthesis based on computer-aided design and computer-aided manufacturing. An ocular prosthesis, based on a three-dimensional (3D) printed impression-free mould of the anophthalmic cavity, was successfully fitted in a 68-year-old male. To the best of our knowledge, this is the first case of a customised ocular prosthesis designed with the aid of 3D printing.Trial registration number B322201628407, Pre-results.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/100/7/879}, eprint = {https://bjo.bmj.com/content/100/7/879.full.pdf}, journal = {British Journal of Ophthalmology} }