@article {Jones1393, author = {N P Jones and L Tsierkezou and N Patton}, title = {Lymphopenia as a predictor of sarcoidosis in patients with uveitis}, volume = {100}, number = {10}, pages = {1393--1396}, year = {2016}, doi = {10.1136/bjophthalmol-2015-307455}, publisher = {BMJ Publishing Group Ltd}, abstract = {Aims To investigate the hypothesis that lymphopenia is an independent predictor of sarcoidosis in new patients presenting with uveitis.Patients and methods Retrospective case{\textendash}control study of 112 patients with sarcoidosis-associated uveitis (SAU) against 398 controls with other forms of uveitis.Results Of the patients with SAU, 30/112 (26.8\%) had significant lymphopenia (\<1.0{\texttimes}109/L), compared with 24/398 (6.0\%) for other uveitis (p<=0.0001, OR 5.7 (95\% CI 3.2 to 10.3)). The mean lymphocyte count for patients with SAU was 1.43 vs 2.04 for other uveitis (p<=0.0001). Logistic regression modelling using diagnosis of SAU as the independent variable identified age, ACE levels and lymphocyte count as independent predictors of SAU. A new patient with uveitis with significant lymphopenia has a risk of sarcoidosis (from this parameter alone) of 31.6\%.Conclusions Significant lymphopenia (\<1.0{\texttimes}109/L) is an independent predictor of sarcoidosis in new patients presenting with uveitis. We recommend that diagnostic criteria for SAU should be modified to include this phenomenon.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/100/10/1393}, eprint = {https://bjo.bmj.com/content/100/10/1393.full.pdf}, journal = {British Journal of Ophthalmology} }