RT Journal Article
SR Electronic
T1 Iris autofluorescence in Fuchs’ heterochromic uveitis
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1397
OP 1402
DO 10.1136/bjophthalmol-2015-307246
VO 100
IS 10
A1 Qian Liu
A1 Yading Jia
A1 Suhua Zhang
A1 Juan Xie
A1 Xin Chang
A1 Jia Hou
A1 Gaiyun Li
A1 Douglas D Koch
A1 Li Wang
YR 2016
UL http://bjo.bmj.com/content/100/10/1397.abstract
AB Aims To explore the characteristic autofluorescence patterns of iris depigmentation in eyes diagnosed with Fuchs’ heterochromic uveitis (FHU).Methods Near-infrared autofluorescence images and colour images of iris were taken in 21 eyes of 21 patients with FHU, 30 eyes of 15 normal subjects, 30 eyes of 15 normal age-related iris atrophy and 33 eyes of 20 patients with uveitis other than FHU. The confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2, HRA2) was used for melanin-related autofluorescence imaging. The indocyanine green angiography mode of HRA2 was applied for near-infrared laser imaging, and the wavelength of the excitation laser was 795 nm. Iris colour images were also taken with the slit lamp.Results In normal iris, moderately intense autofluorescence was noted for the pigment ruff at the pupillary border, the crests in the pupillary zone and the collarette; and there was mild autofluorescence in the ciliary zone. In eyes with age-related iris atrophy and uveitis, much less autofluorescence was seen than the healthy normal irides. In eyes with FHU, there was moderate but discontinuous autofluorescence in the pigment ruff, a petaloid pattern of autofluorescence in the pupillary zone, moderate autofluorescence in the collarette and reticular pattern of autofluorescence in the ciliary zone.Conclusions Characteristic autofluorescence patterns appeared in eyes diagnosed with FHU. Near-infrared autofluorescence is a promising objective technique to document the iris changes in FHU.