PT - JOURNAL ARTICLE AU - Alexander J E Foss AU - Lauren J Scott AU - Chris A Rogers AU - Barney C Reeves AU - Faruque Ghanchi AU - Jonathan Gibson AU - Usha Chakravarthy TI - Changes in intraocular pressure in study and fellow eyes in the IVAN trial AID - 10.1136/bjophthalmol-2015-307595 DP - 2016 Dec 01 TA - British Journal of Ophthalmology PG - 1662--1667 VI - 100 IP - 12 4099 - http://bjo.bmj.com/content/100/12/1662.short 4100 - http://bjo.bmj.com/content/100/12/1662.full SO - Br J Ophthalmol2016 Dec 01; 100 AB - Purpose To describe changes in intraocular pressure (IOP) in the ‘alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)’ trial (registered as ISRCTN92166560).Design Randomised controlled clinical trial with factorial design.Participants Patients (n=610) with treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned to receive either ranibizumab or bevacizumab and to two regimens, namely monthly (continuous) or as needed (discontinuous) treatment.Methods At monthly visits, IOP was measured preinjection in both eyes, and postinjection in the study eye.Outcome measures The effects of 10 prespecified covariates on preinjection IOP, change in IOP (postinjection minus preinjection) and the difference in preinjection IOP between the two eyes were examined.Results For every month in trial, there was a statistically significant rise in both the preinjection IOP and the change in IOP postinjection during the time in the trial (estimate 0.02 mm Hg, 95% CI 0.01 to 0.03, p<0.001 and 0.03 mm Hg, 95% CI 0.01 to 0.04, p=0.002, respectively). There was also a small but significant increase during the time in trial in the difference in IOP between the two eyes (estimate 0.01 mm Hg, 95% CI 0.005 to 0.02, p<0.001). There were no differences between bevacizumab and ranibizumab for any of the three outcomes (p=0.93, p=0.22 and p=0.87, respectively).Conclusions Anti-vascular endothelial growth factor agents induce increases in IOP of small and uncertain clinical significance.Trial registration number ISRCTN92166560.