PT  - JOURNAL ARTICLE
AU  - Alireza Mashaghi
AU  - Jiaxu Hong
AU  - Sunil K Chauhan
AU  - Reza Dana
TI  - Ageing and ocular surface immunity
AID  - 10.1136/bjophthalmol-2015-307848
DP  - 2017 Jan 01
TA  - British Journal of Ophthalmology
PG  - 1--5
VI  - 101
IP  - 1
4099  - http://bjo.bmj.com/content/101/1/1.short
4100  - http://bjo.bmj.com/content/101/1/1.full
SO  - Br J Ophthalmol2017 Jan 01; 101
AB  - The prevalence of ocular surface immunopathologies is enhanced in the elderly. This increased prevalence has been attributed to age-related dysregulation of innate and adaptive immune system responses. Age-related changes in ocular surface immunity have similar and distinct characteristics to those changes seen in other mucosal tissues. This mini review provides a brief outline of key findings in the field of ocular ageing, draws comparisons with other mucosal tissues and, finally, discusses age-related changes in the context of immunopathogenesis of infectious keratitis and dry eye disease, two of the most common inflammatory disorders of the ocular surface.