RT Journal Article
SR Electronic
T1 Ageing and ocular surface immunity
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1
OP 5
DO 10.1136/bjophthalmol-2015-307848
VO 101
IS 1
A1 Alireza Mashaghi
A1 Jiaxu Hong
A1 Sunil K Chauhan
A1 Reza Dana
YR 2017
UL http://bjo.bmj.com/content/101/1/1.abstract
AB The prevalence of ocular surface immunopathologies is enhanced in the elderly. This increased prevalence has been attributed to age-related dysregulation of innate and adaptive immune system responses. Age-related changes in ocular surface immunity have similar and distinct characteristics to those changes seen in other mucosal tissues. This mini review provides a brief outline of key findings in the field of ocular ageing, draws comparisons with other mucosal tissues and, finally, discusses age-related changes in the context of immunopathogenesis of infectious keratitis and dry eye disease, two of the most common inflammatory disorders of the ocular surface.