PT  - JOURNAL ARTICLE
AU  - Blanka Golebiowski
AU  - Noor Badarudin
AU  - John Eden
AU  - Jingjing You
AU  - Ulrike Hampel
AU  - Fiona Stapleton
TI  - Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye?
AID  - 10.1136/bjophthalmol-2016-308473
DP  - 2017 Feb 01
TA  - British Journal of Ophthalmology
PG  - 218--222
VI  - 101
IP  - 2
4099  - http://bjo.bmj.com/content/101/2/218.short
4100  - http://bjo.bmj.com/content/101/2/218.full
SO  - Br J Ophthalmol2017 Feb 01; 101
AB  - Aim To explore the relationship between serum concentration of sex hormones and dry eye symptoms and signs in postmenopausal women.Methods A cross-sectional analysis was undertaken. Subjects were 46 postmenopausal women with dry eye (mean age 64.4±5.2 years, 13.7±6.4 years since menopause; not undergoing hormone replacement therapy). Ocular symptoms (Ocular Surface Disease Index (OSDI) and Ocular Comfort Index (OCI)), tear function (tear osmolarity, non-invasive tear break-up time, tear secretion), corneal and conjunctival staining, and meibomian gland (MG) appearance, were recorded. Venous blood was collected and serum concentrations of 17β-oestradiol (E2), 3-α-androstanediol-glucuronide (3α-diol-G), and dehydroepiandrosterone sulfate (DHEA-S) were determined using ELISA. Multiple linear regression analysis was used to examine predictors of dry eye symptoms and signs.Results Mean serum concentration of E2, 3α-diol-G and DHEA-S was 9.02±13.40 pg/mL, 1.59±1.02 ng/mL and 0.74±0.53 μg/mL, respectively. Ocular symptoms were elevated (mean scores 27.0±18.1 (OSDI) and 40.3±8.4 (OCI)) but signs were within normal ranges. Higher serum E2 concentration along with capped glands, lid telangiectasia and older age was a significant predictor of worse MG secretion quality (p<0.001, R2adj=0.75). Serum hormones were not significant predictors of ocular symptoms in multivariate analysis (p>0.05).Conclusion Serum oestrogen appears to be a key factor in MG signs. Although serum hormone levels did not contribute significantly to dry eye symptoms in this study, it is possible that oestrogen plays a role through its effect on meibum secretion. These findings suggest that MG dysfunction underpins dry eye symptoms in non-Sjögren's dry eye in postmenopausal women.Trial registration number ACTRN12612000281897.