PT  - JOURNAL ARTICLE
AU  - Takamasa Kinoshita
AU  - Yoshinori Mitamura
AU  - Kayo Shinomiya
AU  - Mariko Egawa
AU  - Akiko Iwata
AU  - Akiko Fujihara
AU  - Yoko Ogushi
AU  - Kentaro Semba
AU  - Kei Akaiwa
AU  - Eisuke Uchino
AU  - Shozo Sonoda
AU  - Taiji Sakamoto
TI  - Diurnal variations in luminal and stromal areas of choroid in normal eyes
AID  - 10.1136/bjophthalmol-2016-308594
DP  - 2017 Mar 01
TA  - British Journal of Ophthalmology
PG  - 360--364
VI  - 101
IP  - 3
4099  - http://bjo.bmj.com/content/101/3/360.short
4100  - http://bjo.bmj.com/content/101/3/360.full
SO  - Br J Ophthalmol2017 Mar 01; 101
AB  - Aims To determine the diurnal variations of the luminal and stromal areas of the choroid in normal eyes.Methods This was a prospective observational study of 38 eyes of 38 normal subjects. The blood pressure, heart rate, intraocular pressure and enhanced depth imaging optical coherence tomographic (EDI-OCT) images were recorded every 3 hours between 6:00 and 21:00 hours. The horizontal EDI-OCT images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), total cross-sectional choroidal area, the luminal areas, stromal areas and the ratio of luminal area to total choroidal area (L/C ratio) were determined.Results There were significant diurnal variations in the CCT, total choroidal area, luminal area and L/C ratio with the maximum values at 6:00 hours and the minimum values at 15:00 hours (p<0.001 for the CCT, p=0.011 for the total choroidal area, p<0.001 for the luminal area and p=0.014 for the L/C ratio). There was no significant variation in the stromal area (p=0.216). The range of fluctuation in the CCT was significantly correlated with that in the luminal area and the total choroidal area (p<0.001). However, there was no significant correlation between the fluctuation range in the CCT and that in the stromal area (p=0.095). There was no statistical relationship between the systemic parameters and the choroidal parameters.Conclusions The changes in the luminal area are most likely responsible for the diurnal change in the CCT and subfoveal choroidal area.Trial registration number UMIN000019060, Pre-results.