PT  - JOURNAL ARTICLE
AU  - Tommy C Y Chan
AU  - Marco C Y Yu
AU  - Sammie Mak
AU  - Vishal Jhanji
TI  - Longitudinal comparison of femtosecond-assisted sub-Bowman keratomileusis versus photorefractive keratectomy for high myopia
AID  - 10.1136/bjophthalmol-2016-308642
DP  - 2017 Mar 01
TA  - British Journal of Ophthalmology
PG  - 275--282
VI  - 101
IP  - 3
4099  - http://bjo.bmj.com/content/101/3/275.short
4100  - http://bjo.bmj.com/content/101/3/275.full
SO  - Br J Ophthalmol2017 Mar 01; 101
AB  - Purpose To longitudinally compare the visual and refractive outcomes and changes in corneal thickness between femtosecond-assisted sub-Bowmen keratomileusis (SBK) and photorefractive keratectomy (PRK) with mitomycin C in eyes with high myopia.Methods Patients with spherical equivalent ≥6 dioptres (D) who underwent femtosecond-assisted SBK or PRK with mitomycin C were recruited. All patients were examined preoperatively and after 1 week, and, 1, 3, 6 and 12 months postoperatively. Assessments included uncorrected and best-corrected distance visual acuity , and manifest refraction spherical equivalent. Corneal thickness was measured using swept source optical coherence tomography.Results A total of 110 eyes were included (68 PRK, 42 SBK). Change in efficacy index and safety index was not significantly different between both groups beyond 1 week postoperatively (p≥0.116). Manifest refraction spherical equivalent changed significantly from −9.02±1.92 D preoperatively to −0.21±0.31 D and from −8.25±1.10 D preoperatively to −0.53±0.55 D at 1 year after PRK and SBK, respectively (p&amp;lt;0.0001). The variance of postoperative refraction was significantly smaller after PRK throughout the 1-year follow-up compared with SBK (p≤0.0024). The central corneal thickness stabilised at 1 week after PRK and 3 months after SBK.Conclusions Our study showed that femtosecond-assisted SBK and PRK with mitomycin C have comparable safety and efficacy for correction of high myopia. However, better predictability of postoperative refraction was noted after PRK compared with SBK.