TY - JOUR T1 - Natural history and effect of therapeutic interventions on subretinal fluid causing foveal detachment in macular telangiectasia type 2 JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 955 LP - 959 DO - 10.1136/bjophthalmol-2016-309237 VL - 101 IS - 7 AU - Hemal Mehta AU - Simone Müller AU - Catherine A Egan AU - Simona Degli Esposti AU - Adnan Tufail AU - Dawn A Sim AU - Frank G Holz AU - Andrew C Browning AU - Winfried M Amoaku AU - Peter Charbel Issa AU - Mark C Gillies Y1 - 2017/07/01 UR - http://bjo.bmj.com/content/101/7/955.abstract N2 - Aim To report the natural history of subretinal fluid (SRF) causing foveal detachment in macular telangiectasia type 2 (MacTel) and our experience of therapeutic intervention with intravitreal steroids or antivascular endothelial growth factor inhibitor (anti-VEGF) agents in some cases.Methods Retrospective case series. Three of the MacTel study's largest registries were searched to identify eyes with foveal detachment.Results We identified 7 eyes from 6 exclusively female patients. The prevalence of foveal detachment was low, present in 1.4% of the assessed MacTel population. Age at presentation ranged from 50 to 66 years. Follow-up ranged from 2 to 8 years. There was late-phase leakage on fluorescein angiography from what was presumed to be ectatic capillaries. The SRF fluctuated without a rapid decline in visual acuity in cases that were not treated. When they were, intravitreal anti-VEGF and steroid therapy in general reduced SRF, at least temporarily, but did not halt the gradual long-term decrease in visual acuity. In one case, optical coherence tomography angiography showed significant reduction in the extent of the predominantly deep intraretinal vascular complex 1 month after anti-VEGF therapy.Discussion and conclusions As the natural history of this unusual MacTel phenotype is not characterised by rapid visual decline, intervention with intravitreal anti-VEGF or steroid therapy may not be necessary. ER -