PT  - JOURNAL ARTICLE
AU  - Handan Akil
AU  - Vikas Chopra
AU  - Mayss Al-Sheikh
AU  - Khalil Ghasemi Falavarjani
AU  - Alex S Huang
AU  - SriniVas R Sadda
AU  - Brian A Francis
TI  - Swept-source OCT angiography imaging of the macular capillary network in glaucoma
AID  - 10.1136/bjophthalmol-2016-309816
DP  - 2017 Aug 09
TA  - British Journal of Ophthalmology
PG  - bjophthalmol-2016-309816
4099  - http://bjo.bmj.com/content/early/2017/08/09/bjophthalmol-2016-309816.short
4100  - http://bjo.bmj.com/content/early/2017/08/09/bjophthalmol-2016-309816.full
AB  - Purpose To evaluate the macular capillary network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects.Method In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6×6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL.Results The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with POAG (SRL, p&amp;lt;0.001; DRL, p&amp;lt;0.001). In the SRL, the mean±SD VD ratio was 0.34±0.05 in patients with POAG and 0.40±0.02 in normal individuals (p&amp;lt;0.001). In the DRL, the mean (SD) ratio was 0.37±0.05 in patients with POAG and 0.43±0.02 in normal individuals (p&amp;lt;0.001). The mean VD at the SRL was significantly correlated with ganglion cell inner plexiform layer thickness (r=0.42, p=0.04) but not with visual field mean deviation (r=0.4, p=0.06) and retinal nerve fibre layer thickness (r=0.5, p=0.06). The mean VD at the DRL did not show significant correlation with any other glaucoma parameter (p&amp;gt;0.05).Conclusion The assessment of macular VD by swept-source OCTA may offer additional information for detection of glaucoma.