RT Journal Article
SR Electronic
T1 Peripapillary perfused capillary density in primary open<strong>-</strong>angle glaucoma across disease stage<strong>:</strong> an optical coherence tomography angiography study
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1261
OP 1268
DO 10.1136/bjophthalmol-2016-309642
VO 101
IS 9
A1 Lawrence S Geyman
A1 Reena A Garg
A1 Yanin Suwan
A1 Vivek Trivedi
A1 Brian D Krawitz
A1 Shelley Mo
A1 Alexander Pinhas
A1 Apichat Tantraworasin
A1 Toco Y P Chui
A1 Robert Ritch
A1 Richard B Rosen
YR 2017
UL http://bjo.bmj.com/content/101/9/1261.abstract
AB Aims To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease.Methods In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optical coherence tomography angiography system (AngioVue, Optovue, Fremont, California, USA) generating images centred on the optic nerve head. Major blood vessels were removed using custom automated software. PCD was calculated as a percentage as the ratio of pixels associated with perfused capillaries to the total number of pixels in the corresponding region-of-interest (ROI). Analysis of covariance was used to compare PCD among the subject groups and control for possible covariates. Area under the receiver operating characteristic curve (AROC) and sensitivity at 95% specificity were calculated to assess the capability of PCD to distinguish mild glaucoma from control. The Pearson's product-moment correlation coefficient was used to assess correlations between PCD and circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field mean deviation (MD).Results PCD demonstrated a progressive stepwise decrease from control eyes throughout worsening POAG stage at all ROIs. PCD demonstrated AROC and sensitivity values comparable to cpRNFLT and visual field parameters and exhibited significant correlations with cpRNFLT and MD at all corresponding ROIs.Conclusions PCD displayed significant correlations with morphological and functional indices and exhibited diagnostic capabilities comparable to currently employed clinical variables. Our preliminary results suggest that PCD analysis may prove to be a useful tool in monitoring POAG across stage and identifying early POAG.