RT Journal Article
SR Electronic
T1 Association of iris crypts with acute primary angle closure
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1318
OP 1322
DO 10.1136/bjophthalmol-2016-309842
VO 101
IS 10
A1 Victor Koh
A1 Jacqueline Chua
A1 Yuan Shi
A1 Sri Gowtham Thakku
A1 Ryan Lee
A1 Monisha E Nongpiur
A1 Mani Baskaran
A1 Rajesh S Kumar
A1 Shamira Perera
A1 Tin Aung
A1 Ching-Yu Cheng
YR 2017
UL http://bjo.bmj.com/content/101/10/1318.abstract
AB Purpose To determine the relationship between iris surface features and acute primary angle closure (APAC) in eyes with angle closure.Design Case-control study involving Asian patients diagnosed with previous APAC, primary angle closure suspect (PACS), primary angle closure (PAC) and primary angle closure glaucoma (PACG) at an eye centre in Singapore between August 2012 and January 2015.Methods Participants underwent ophthalmic examination and digital slit-lamp iris photography. Iris surface features were graded based on crypts, furrows and colour. Fellow eyes of APAC were compared with PACS and PAC/PACG eyes with regard to their iris surface features.Main outcome measure Occurrence of APAC.Results A total of 309 patients (71 APAC, 139 PACS, 47 PAC and 52 PACG) were included (mean age: 67.7±7.2 years and 36.6% male). Compared with PACS, higher crypt grade was significantly associated with lower odds of APAC (OR=0.58 for one grade higher in crypt grade; p=0.027, adjusted for age, gender, ethnicity and pupil diameter). The results remained similar when compared with PAC/PACG group (OR=0.58 for one grade higher in crypt grade; p=0.043). We did not observe any significant associations between iris furrows or colour with presence of APAC.Conclusions Our study comprising Asian eyes with angle closure suggests that the presence of a higher crypt grading may be protective for APAC. As such, assessing iris surface architecture for crypts could be a new measure for risk stratification of developing APAC in eyes with angle closure.