RT Journal Article
SR Electronic
T1 Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2017-311000
DO 10.1136/bjophthalmol-2017-311000
A1 Abhilash Guduru
A1 Marco Lupidi
A1 Arushi Gupta
A1 Subhadra Jalali
A1 Jay Chhablani
YR 2017
UL http://bjo.bmj.com/content/early/2017/10/26/bjophthalmol-2017-311000.abstract
AB Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging.Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated.Results Twenty-two patients suffering from different stages of STGD were enrolled. OCTA revealed a vascular rarefaction with vascular prominence in 15 (35%) eyes while the remaining cases had pure vascular rarefaction. On FAF imaging, 25 (58%) eyes had a peripapillary halo, a hypofluorescent lesion in foveal area and the presence of both hypofluorescent and hyperfluorescent changes. On FAF imaging, the average area of RPE impairment was 6.7±4.4 mm2 while on OCTA a hypointense area of 4.2±3.6 mm2 was shown at the level of the CC layer. Mann-Whitney U test showed a statistically significant difference in terms of lesion extension between these two findings (p=0.004).Conclusion RPE damage on FAF appears to be significantly larger than CC layer vessel loss on OCTA, which suggests that RPE damage might precede that of CC.