RT Journal Article
SR Electronic
T1 Calculating the individual probability of successful ocriplasmin treatment in eyes with VMT syndrome: a multivariable prediction model from the EXPORT study
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2017-310874
DO 10.1136/bjophthalmol-2017-310874
A1 Christoph Paul
A1 Christine Heun
A1 Hans-Helge Müller
A1 Hans Hoerauf
A1 Nicolas Feltgen
A1 Joachim Wachtlin
A1 Hakan Kaymak
A1 Stefan Mennel
A1 Michael Janusz Koss
A1 Sascha Fauser
A1 Mathias M Maier
A1 Ricarda G Schumann
A1 Simone Mueller
A1 Petrus Chang
A1 Steffen Schmitz-Valckenberg
A1 Sara Kazerounian
A1 Peter Szurman
A1 Albrecht Lommatzsch
A1 Thomas Bertelmann
YR 2017
UL http://bjo.bmj.com/content/early/2017/10/31/bjophthalmol-2017-310874.abstract
AB Background/Aims To evaluate predictive factors for the treatment success of ocriplasmin and to use these factors to generate a multivariate model to calculate the individual probability of successful treatment.Methods Data were collected in a retrospective, multicentre cohort study. Patients with vitreomacular traction (VMT) syndrome without a full-thickness macular hole were included if they received an intravitreal injection (IVI) of ocriplasmin. Five factors (age, gender, lens status, presence of epiretinal membrane (ERM) formation and horizontal diameter of VMT) were assessed on their association with VMT resolution. A multivariable logistic regression model was employed to further analyse these factors and calculate the individual probability of successful treatment.Results 167 eyes of 167 patients were included. Univariate analysis revealed a significant correlation to VMT resolution for all analysed factors: age (years) (OR 0.9208; 95% CI 0.8845 to 0.9586; p<0.0001), gender (male) (OR 0.480; 95% CI 0.241 to 0.957; p=0.0371), lens status (phakic) (OR 2.042; 95% CI 1.054 to 3.958; p=0.0344), ERM formation (present) (OR 0.384; 95% CI 0.179 to 0.821; p=0.0136) and horizontal VMT diameter (µm) (OR 0.99812; 95% CI 0.99684 to 0.99941, p=0.0042). A significant multivariable logistic regression model was established with age and VMT diameter.Conclusion Known predictive factors for VMT resolution after ocriplasmin IVI were confirmed in our study. We were able to combine them into a formula, ultimately allowing the calculation of an individual probability of treatment success with ocriplasmin in patients with VMT syndrome without FTHM.