PT  - JOURNAL ARTICLE
AU  - Shuichiro Aoki
AU  - Hiroshi Murata
AU  - Yuri Fujino
AU  - Masato Matsuura
AU  - Atsuya Miki
AU  - Masaki Tanito
AU  - Shiro Mizoue
AU  - Kazuhiko Mori
AU  - Katsuyoshi Suzuki
AU  - Takehiro Yamashita
AU  - Kenji Kashiwagi
AU  - Kazunori Hirasawa
AU  - Nobuyuki Shoji
AU  - Ryo Asaoka
TI  - Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma
AID  - 10.1136/bjophthalmol-2016-310069
DP  - 2017 Dec 01
TA  - British Journal of Ophthalmology
PG  - 1658--1665
VI  - 101
IP  - 12
4099  - http://bjo.bmj.com/content/101/12/1658.short
4100  - http://bjo.bmj.com/content/101/12/1658.full
SO  - Br J Ophthalmol2017 Dec 01; 101
AB  - Background/aims To investigate the usefulness of the Octopus (Haag-Streit) EyeSuite’s cluster trend analysis in glaucoma.Methods Ten visual fields (VFs) with the Humphrey Field Analyzer (Carl Zeiss Meditec), spanning 7.7 years on average were obtained from 728 eyes of 475 primary open angle glaucoma patients. Mean total deviation (mTD) trend analysis and EyeSuite’s cluster trend analysis were performed on various series of VFs (from 1st to 10th: VF1-10 to 6th to 10th: VF6-10). The results of the cluster-based trend analysis, based on different lengths of VF series, were compared against mTD trend analysis.Result Cluster-based trend analysis and mTD trend analysis results were significantly associated in all clusters and with all lengths of VF series. Between 21.2% and 45.9% (depending on VF series length and location) of clusters were deemed to progress when the mTD trend analysis suggested no progression. On the other hand, 4.8% of eyes were observed to progress using the mTD trend analysis when cluster trend analysis suggested no progression in any two (or more) clusters.Conclusion Whole field trend analysis can miss local VF progression. Cluster trend analysis appears as robust as mTD trend analysis and useful to assess both sectorial and whole field progression. Cluster-based trend analyses, in particular the definition of two or more progressing cluster, may help clinicians to detect glaucomatous progression in a timelier manner than using a whole field trend analysis, without significantly compromising specificity.