TY - JOUR T1 - Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1658 LP - 1665 DO - 10.1136/bjophthalmol-2016-310069 VL - 101 IS - 12 AU - Shuichiro Aoki AU - Hiroshi Murata AU - Yuri Fujino AU - Masato Matsuura AU - Atsuya Miki AU - Masaki Tanito AU - Shiro Mizoue AU - Kazuhiko Mori AU - Katsuyoshi Suzuki AU - Takehiro Yamashita AU - Kenji Kashiwagi AU - Kazunori Hirasawa AU - Nobuyuki Shoji AU - Ryo Asaoka Y1 - 2017/12/01 UR - http://bjo.bmj.com/content/101/12/1658.abstract N2 - Background/aims To investigate the usefulness of the Octopus (Haag-Streit) EyeSuite’s cluster trend analysis in glaucoma.Methods Ten visual fields (VFs) with the Humphrey Field Analyzer (Carl Zeiss Meditec), spanning 7.7 years on average were obtained from 728 eyes of 475 primary open angle glaucoma patients. Mean total deviation (mTD) trend analysis and EyeSuite’s cluster trend analysis were performed on various series of VFs (from 1st to 10th: VF1-10 to 6th to 10th: VF6-10). The results of the cluster-based trend analysis, based on different lengths of VF series, were compared against mTD trend analysis.Result Cluster-based trend analysis and mTD trend analysis results were significantly associated in all clusters and with all lengths of VF series. Between 21.2% and 45.9% (depending on VF series length and location) of clusters were deemed to progress when the mTD trend analysis suggested no progression. On the other hand, 4.8% of eyes were observed to progress using the mTD trend analysis when cluster trend analysis suggested no progression in any two (or more) clusters.Conclusion Whole field trend analysis can miss local VF progression. Cluster trend analysis appears as robust as mTD trend analysis and useful to assess both sectorial and whole field progression. Cluster-based trend analyses, in particular the definition of two or more progressing cluster, may help clinicians to detect glaucomatous progression in a timelier manner than using a whole field trend analysis, without significantly compromising specificity. ER -