TY - JOUR T1 - Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 126 LP - 130 DO - 10.1136/bjophthalmol-2016-310042 VL - 102 IS - 1 AU - Alex D Pechauer AU - Thomas S Hwang AU - Ahmed M Hagag AU - Liang Liu AU - Ou Tan AU - Xinbo Zhang AU - Maria Parker AU - David Huang AU - David J Wilson AU - Yali Jia Y1 - 2018/01/01 UR - http://bjo.bmj.com/content/102/1/126.abstract N2 - Aim To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT).Methods A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane. DR severity was graded according to the international clinical classification system. The generalised linear model method was used to compare flow values between DR groups and the control group.Results A total of 71 eyes from 71 participants were included. Ten eyes were excluded due to poor image quality. The within-visit repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy (46.7±10.2 µL/min) and mild/moderate non-proliferative DR (44.9±12.6 µL/min) groups. The TRBF in severe non-proliferative DR (39.1±12.6 µL/min) and proliferative DR (28.9±8.85 µL/min) groups were significantly lower (p=0.04 and p<0.0001, respectively) than that of the healthy group. TRBF was correlated with DR disease severity (p<0.0001, linear trend test).Conclusion The novel multiplane en face Doppler OCT method provided reliable measurements of TRBF in DR eyes. This may be a useful tool in understanding the pathophysiology of DR. ER -