RT Journal Article
SR Electronic
T1 Neuroretinal atrophy following resolution of macular oedema in retinal vein occlusion
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2017-311614
DO 10.1136/bjophthalmol-2017-311614
A1 Dominika Podkowinski
A1 Ana-Maria Philip
A1 Wolf-Dieter Vogl
A1 Jutta Gamper
A1 Hrvoje Bogunovic
A1 Bianca S Gerendas
A1 Bilal Haj Najeeb
A1 Sebastian M Waldstein
A1 Ursula Schmidt-Erfurth
YR 2018
UL http://bjo.bmj.com/content/early/2018/03/05/bjophthalmol-2017-311614.abstract
AB Background/aims To characterise neuroretinal atrophy in retinal vein occlusion (RVO).Methods We included patients with central/branch RVO (CRVO=196, BRVO=107) who received ranibizumab according to a standardised protocol for 6 months. Retinal atrophy was defined as the presence of an area of retinal thickness (RT) <260 µm outside the foveal centre. Moreover, the thickness of three distinct retinal layer compartments was computed as follows: (1) retinal nerve fibre layer to ganglion cell layer, (2) inner plexiform layer (IPL) to outer nuclear layer (ONL) and (3) inner segment/outer segment junction to retinal pigment epithelium. To characterise atrophy further, we assessed perfusion status on fluorescein angiography and best-corrected visual acuity (BCVA), and compared these between eyes with/without atrophy.Results 23 patients with CRVO and 11 patients with BRVO demonstrated retinal atrophy, presenting as sharply demarcated retinal thinning confined to a macular quadrant. The mean RT in the atrophic quadrant at month 6 was 249±26 µm (CRVO) and 244±29 µm (BRVO). Individual layer analysis revealed pronounced thinning in the IPL to ONL compartment. Change in BCVA at 6 months was similar between the groups (BRVO, +15 vs +18 letters; CRVO, +14 vs +18 letters).Conclusions In this exploratory analysis, we describe the characteristics of neuroretinal atrophy in RVO eyes with resolved macular oedema after ranibizumab therapy. Our analysis shows significant, predominantly retinal thinning in the IPL to ONL compartment in focal macular areas in 11% of patients with RVO. Eyes with retinal atrophy did not show poorer BCVA outcomes.