RT Journal Article
SR Electronic
T1 Swept-source OCT angiography imaging of the macular capillary network in glaucoma
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 515
OP 519
DO 10.1136/bjophthalmol-2016-309816
VO 102
IS 4
A1 Handan Akil
A1 Vikas Chopra
A1 Mayss Al-Sheikh
A1 Khalil Ghasemi Falavarjani
A1 Alex S Huang
A1 SriniVas R Sadda
A1 Brian A Francis
YR 2018
UL http://bjo.bmj.com/content/102/4/515.abstract
AB Purpose To evaluate the macular capillary network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects.Method In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6×6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL.Results The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with POAG (SRL, p<0.001; DRL, p<0.001). In the SRL, the mean±SD VD ratio was 0.34±0.05 in patients with POAG and 0.40±0.02 in normal individuals (p<0.001). In the DRL, the mean (SD) ratio was 0.37±0.05 in patients with POAG and 0.43±0.02 in normal individuals (p<0.001). The mean VD at the SRL was significantly correlated with ganglion cell inner plexiform layer thickness (r=0.42, p=0.04) but not with visual field mean deviation (r=0.4, p=0.06) and retinal nerve fibre layer thickness (r=0.5, p=0.06). The mean VD at the DRL did not show significant correlation with any other glaucoma parameter (p>0.05).Conclusion The assessment of macular VD by swept-source OCTA may offer additional information for detection of glaucoma.