TY - JOUR T1 - Adaptive optics imaging of inherited retinal diseases JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1028 LP - 1035 DO - 10.1136/bjophthalmol-2017-311328 VL - 102 IS - 8 AU - Michalis Georgiou AU - Angelos Kalitzeos AU - Emily J Patterson AU - Alfredo Dubra AU - Joseph Carroll AU - Michel Michaelides Y1 - 2018/08/01 UR - http://bjo.bmj.com/content/102/8/1028.abstract N2 - Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this in vivo microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date. ER -