PT  - JOURNAL ARTICLE
AU  - Takao Hirano
AU  - Shinji Kakihara
AU  - Yuichi Toriyama
AU  - Muneeswar Gupta Nittala
AU  - Toshinori Murata
AU  - Srinivas Sadda
TI  - Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy
AID  - 10.1136/bjophthalmol-2017-311358
DP  - 2018 Sep 01
TA  - British Journal of Ophthalmology
PG  - 1199--1203
VI  - 102
IP  - 9
4099  - http://bjo.bmj.com/content/102/9/1199.short
4100  - http://bjo.bmj.com/content/102/9/1199.full
SO  - Br J Ophthalmol2018 Sep 01; 102
AB  - Aims To examine the feasibility of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) with extended field imaging (EFI) for evaluation of the retinal vasculature in diabetic retinopathy (DR).Methods This study included 37 eyes of 27 patients (age, 65±10 years; male patients, 18; female patients, 9) with DR. All patients underwent comprehensive ophthalmological examination, including OCTA and fluorescein angiography (FA). The imaging methods were compared for visible field of view, presence and extent of non-perfused areas (NPAs), presence and number of new blood vessels (NVs), vessel density (VD) and patient comfort level measured by Visual Analogue Scale.Results SS-OCTA with EFI allowed capture of larger areas (by 1.80±0.18 times on average) of the fundus than SS-OCTA without EFI. Compared with FA, the sensitivities of SS-OCTA with EFI for detection of NPAs and NVs were 96% and 79%, respectively, with specificities of 100% and 96%, respectively. There was no significant difference in extent of NPAs (61.2±45.8 vs 61.5±55.0 disc areas, P=0.99) or number of NVs (1.5±3.3 vs 0.9±1.8, P=0.68) between FA and SS-OCTA with EFI. VD showed significantly lower values in EFI SS-OCTA than in those acquired without EFI (31.6%±4.3%  vs 34.2%±4.3%, P<0.001). Wide-field OCTA with EFI was significantly more comfortable for patients than FA (P<0.001).Conclusions SS-OCTA with EFI allows acquisition of wide-field en face images of the retinal vasculature in patients with DR, with greater patient comfort than FA.