PT - JOURNAL ARTICLE AU - Nicole Carnt, PhD AU - Jeremy J Hoffman, MBBS AU - Seema Verma AU - Scott Hau AU - Cherry F Radford, PhD AU - Darwin C Minassian AU - John K G Dart TI - <em>Acanthamoeba</em> keratitis: confirmation of the UK outbreak and a prospective case-control study identifying contributing risk factors AID - 10.1136/bjophthalmol-2018-312544 DP - 2018 Dec 01 TA - British Journal of Ophthalmology PG - 1621--1628 VI - 102 IP - 12 4099 - http://bjo.bmj.com/content/102/12/1621.short 4100 - http://bjo.bmj.com/content/102/12/1621.full SO - Br J Ophthalmol2018 Dec 01; 102 AB - Background/aims Acanthamoeba keratitis (AK) is a chronic debilitating corneal infection principally affecting contact lens (CL) users. Studies were designed to test claims that the UK incidence may have increased in 2012–2014 and to evaluate potential causes.Methods Annualised incidence data were collected from January 1984 to December 2016. Case-control study subjects were recruited between 14 April 2011 and 05 June 2017. Reusable CL users with AK were recruited retrospectively and prospectively. Controls were reusable CL users, recruited prospectively, with any disorder other than AK. Multivariable analysis of questionnaire data measured independent risk factors for AK.Results The current outbreak of AK started in 2010–2011 with an incidence threefold higher than in 2004–2009. Risk factors for AK were: Oxipol disinfection, CLs made of group IV CL materials, poor CL hygiene, deficient hand hygiene, use of CLs while swimming or bathing, being white British, and for those in social classes 4–9.Conclusion AK is a largely preventable disease. The current outbreak is unlikely to be due to any one of the identified risk factors in isolation. Improving CL and hand hygiene, avoiding CLs contamination with water and use of effective CL disinfection solutions, or daily disposable CLs, will reduce the incidence of AK. In the longer-term, water avoidance publicity for CL users can be expected to reduce the incidence further. Ongoing surveillance of AK numbers will identify changes in incidence earlier. Evaluation of Acanthamoeba contamination in end-user drinking water would contribute to our understanding of regional variations in the risk of exposure.