@article {Jun573, author = {Ikhyun Jun and John Hoon Rim and Mee Kum Kim and Kyung-Chul Yoon and Choun-Ki Joo and Shigeru Kinoshita and Kyoung Yul Seo and Mayumi Ueta}, title = {Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population}, volume = {103}, number = {4}, pages = {573--576}, year = {2019}, doi = {10.1136/bjophthalmol-2018-313263}, publisher = {BMJ Publishing Group Ltd}, abstract = {Background/aims Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population.Methods This multicentre case-control study enrolled 40 Korean patients with CM-SJS/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes.Results~The carrier frequency and gene frequency of HLA-A*02:06 were 37.5 \% and 20.0 \%, respectively, in patients, and 16.7 \% and 9.6 \%, respectively, in controls (p=0.018). The carrier frequency of HLA-C*03:04 was 30 \% in patients and 10.8 \% in controls, and gene frequency of HLA-C*03:04 was 15 \% in patients and 5.4 \% in controls (p=0.003). The carrier frequency and gene frequency of HLA-C*03:03 were 2.5 \% and 1.3 \%, respectively, in patients, and 20 \% and 10.4 \%, respectively, in controls (p=0.006).Conclusions~As per our results, we suggest that HLA-A*02:06 and HLA-C*03:04 might be positive markers for CM-SJS/TEN with SOC, and HLA-C*03:03 might be an indicator of protection against CM-SJS/TEN with SOC in the Korean population.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/103/4/573}, eprint = {https://bjo.bmj.com/content/103/4/573.full.pdf}, journal = {British Journal of Ophthalmology} }