PT - JOURNAL ARTICLE AU - Li-min Chen AU - Li-juan Wang AU - Yang Hu AU - Xiao-han Jiang AU - Yu-zhi Wang AU - Ying-qi Xing TI - Ultrasonic measurement of optic nerve sheath diameter: a non-invasive surrogate approach for dynamic, real-time evaluation of intracranial pressure AID - 10.1136/bjophthalmol-2018-312934 DP - 2019 Apr 01 TA - British Journal of Ophthalmology PG - 437--441 VI - 103 IP - 4 4099 - http://bjo.bmj.com/content/103/4/437.short 4100 - http://bjo.bmj.com/content/103/4/437.full SO - Br J Ophthalmol2019 Apr 01; 103 AB - The current study aimed to identify whether ultrasonographic measurements of optic nerve sheath diameter (ONSD) could dynamically and sensitively evaluate real-time intracranial pressure (ICP). ONSD measurements were performed approximately 5  min prior to and after a lumbar puncture (LP). A total of 84 patients (mean±SD age, 43.5±14.7 years; 41 (49%) men; 18 patients with elevated ICP) were included in the study. The Spearman correlation coefficients between the two observers were 0.779 and 0.703 in the transverse section and 0.751 and 0.788 in the vertical section for the left and right eyes, respectively. The median (IQR) change in ONSD (ΔONSD) and change in ICP (ΔICP) were 0.11 (0.05–0.21) mm and 30 (20–40) mmH2O, respectively, for all participants. With a reduction in cerebrospinal fluid pressure, 80 subjects (95%) showed an immediate drop in ONSD; the median (IQR) decreased from 4.13 (4.02–4.38) mm to 4.02 (3.90–4.23) mm (p<0.001). Significant correlations were found between ONSD and ICP before LPs (r=0.482, p<0.01) and between ΔONSD and ΔICP (r=0.451, p<0.01). Ultrasonic measurement of ONSD can reflect the relative real-time changes in ICP.