PT  - JOURNAL ARTICLE
AU  - Gerald Liew
AU  - Stacey Strong
AU  - Patrick Bradley
AU  - Philip Severn
AU  - Anthony T Moore
AU  - Andrew R Webster
AU  - Paul Mitchell
AU  - Annette Kifley
AU  - Michel Michaelides
TI  - Prevalence of cystoid macular oedema, epiretinal membrane and cataract in retinitis pigmentosa
AID  - 10.1136/bjophthalmol-2018-311964
DP  - 2019 Aug 01
TA  - British Journal of Ophthalmology
PG  - 1163--1166
VI  - 103
IP  - 8
4099  - http://bjo.bmj.com/content/103/8/1163.short
4100  - http://bjo.bmj.com/content/103/8/1163.full
SO  - Br J Ophthalmol2019 Aug 01; 103
AB  - Background/Aims To report the prevalence of treatable complications (cystoid macular oedema, CME; epiretinal membrane, ERM and cataract) in patients with retinitis pigmentosa (RP).Methods Consecutive patients with RP attending a tertiary eye clinic in 2012. Spectral domain-optical coherence tomography was used to determine presence of CME and ERM. Clinic records were reviewed to identify cataract and pseudophakia. Multivariable analyses adjusted for age, gender and other confounders.Results Data are presented for 338 eyes from 169 patients. CME was present in 58.6% of patients and 50.9% of eyes and was bilateral in 73.7%. ERM, cataract and pseudophakia were present in 22.8%, 23.4% and 11.2% eyes, respectively. In multivariable analyses, CME was associated with younger age (OR 0.81, 95% CI 0.67 to 0.98) but not with gender. Patients with ERM and cataract/pseudophakia were less likely to also have CME (OR 0.19, 95% CI 0.09 to 0.40 and OR 0.37, 95% CI 0.16 to 0.84, respectively). CME was most prevalent in patients with autosomal-dominant inheritance (71.4%), followed by autosomal recessive/sporadic inheritance (58.9%) and least likely in persons with X linked inheritance (12.5%, p<0.001).Conclusions The prevalence of treatable RP complications is high and suggests it may be clinically beneficial to screen patients with RP to identify those who may benefit from current or future interventions.